Journal: International Journal of Nanomedicine
Article Title: A novel nanoemulsion-based method to produce ultrasmall, water-dispersible nanoparticles from chitosan, surface modified with cell-penetrating peptide for oral delivery of proteins and peptides
doi: 10.2147/IJN.S116063
Figure Lengend Snippet: Effect of different formulations on TEER. Notes: A, simple solution of regular human insulin (1.6 mg/mL); B, simple solution of aspart insulin (1.6 mg/mL); C, dispersion of plain CS NPs (10 mg/mL); D, CPP-conjugated CS NPs loaded with regular human insulin (10 mg/mL); E, CPP-conjugated CS NPs loaded with aspart insulin (10 mg/mL); F, simple solution of CPP (PenetraMax; 10 µM/mL). Abbreviations: CPP, cell-penetrating peptide; CS, chitosan; NPs, nanoparticles; TEER, transepithelial electrical resistance.
Article Snippet: Aliquots were taken from the receiver chamber at predetermined time intervals and continued for 4 h, and the samples were investigated for insulin content with a special ELISA kit specific and sensitive to both regular human insulin and aspart insulin (Alpha Diagnostic International).
Techniques: